Figure 7.

Model: role of LmjMCA in cell death. Apoptosis stimuli would induce LmjMCA processing, releasing the catalytic domain, notably the catalytic domain ranging from aa 136 to 218. The catalytic domain, via its catalytic dyad His/Cys, would enzymatically activate substrates through their processing, and the C-terminal domain would interact with proteins involved in stress regulation or programmed cell death like LmaMPK7 and the calpain-like cysteine peptidase, independently of any enzymatic activity. These two pathways would trigger the apoptosis phenotype