Table 1. Hypothetical proteins of L. major parasites identified as interacting with LmjMCA.
| Protein libraries | Reference of hypothetical protein sequence and predicted functional domaina | ||
|---|---|---|---|
| 147/202LmjMCA | Logarithmic promastigotes | LmjF.24.1570: RNA-binding domain | LmjF.21.0820 LmjF.26.2650 |
| Stationary promastigotes | LmjF.10.0620: twin arginine translocation signal domain LmjF.17.1270: ferredoxin domain LmjF.19.0330: WD40 repeat LmjF.31.1320: phosphatase domain LmjF.35.1620: concanavalin A/glucanase domain LmjF.35.4350: signal peptide/PGAP1-like domain LmjF.36.3340: signal peptide LmjF.25.2200: Parkin co-regulated protein domain LmjF.35.0610: signal peptide | LmjF.21.0905 LmjF.22.0100 LmjF.23.1075 LmjF.27.0850 LmjF.30.3620 LmjF.31.1540 LmjF.30.1390 LmjF.36.5210 | |
| Axenic amastigotes | LmjF.06.0850: signal peptide LmjF.18.1050: heat shock protein DnaJ domain LmjF.19.1410: polyA polymerase domain LmjF.25.0770: signal peptide (4) LmjF.27.0020: signal peptide/EGF-like domain LmjF.30.0950: WD40 repeat LmjF.30.1190: transcription factor domain LmjF.30.1810: signal peptide/PapD-like domain LmjF.30.2390: signal peptide/RNI-like domain LmjF.30.3310: MORN motif (2) LmjF.31.0680: C2 domain LmjF.31.1020: signal peptide/GPI-anchor LmjF.31.1210: ubiquitin domain/zinc finger, RanBP2-type LmjF.31.1330: nucleotide binding LmjF.33.1460: RNA binding LmjF.33.1490: tetratricopeptide repeat LmjF.35.1020: Zn finger (3) LmjF.35.1040: Zn finger | LmjF.14.0300 LmjF.19.0020 (2) LmjF.20.1700 (2) LmjF.22.0100 LmjF.31.1540 LmjF.34.1370 LmjF.09.1300 LmjF.16.1210 LmjF.25.1350 LmjF.31.0210 LmjF.35.0960 | |
| Intracellular amastigotes | LmjF.22.0410: signal peptide/mannose-6-phosphate receptor binding domain/growth factor receptor domain LmjF.24.1390: Zn finger/EF hand domain LmjF.25.0770: signal peptide LmjF.35.0610: signal peptide | LmjF.22.0100 LmjF.22.1440 | |
| 202 cd-LmjMCA | Stationary promastigotes | LmjF.15.0310 | |
Reiterative proteins were found in more than one life cycle stage of L. major parasites (in bold), and in two (2), three (3) or four (4) yeast colonies
a
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