Figure 1.

Model of Hippo/YAP involvement in Schwann cells of the peripheral nervous system. Hippo/YAP participate in forming tight junction and cell-to-cell adhesion in Schwann cells. A potential injury or an environmental challenge, as the exposure to a 50-Hz electromagnetic field, may induce a merlin-dependent Hippo/YAP activation, in turn affecting cell proliferation, migration, chemotactic responsivity and differentiation. In principle, these mechanisms are supposed to be involved in nerve tumorigenesis and schwannoma development⁹