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. 2015 Oct 22;6(10):e1943. doi: 10.1038/cddis.2015.295

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Co-localization of Pur-alpha with mutated FUS in motoneurons differentiated from IPSCs. (a) Untreated motoneurons differentiated from IPSC cells, which derived from ALS patients or from healthy donor (WT), were labeled by immunofluorescence with anti-Pur-alpha and anti-FUS antibodies (bars=10 μm). (b) Same motoneurons shown in (a) were treated with 0.5 mM of sodium arsenite for 90 min to induce the formation of stress granules and stained by immunofluorescence with anti-Pur-alpha and anti-FUS antibodies (bars=10 μm)