Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct 15;6(10):e1924. doi: 10.1038/cddis.2015.296

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Only high concentrations of active sc-tPA promote excitotoxicity. (a) Cortical neurons (12-13 DIV) were exposed for 1 h to NMDA (50 μM) in the presence of sc-tPA or tc-tPA. Neuronal death was quantified 24 h later. (b and c) Same experiments as in panel (a) were performed with neurons exposed for 24 h to NMDA (10 μM) in the presence of sc-tPA alone or in combination with tPA stop (10 nM, b) or GluN1 antibody (10 μg/ml, c). (mean±S.E.M.; n=3 experiments; 4 wells per condition; *P<0.05, NS: not significant, Kruskal–Wallis test followed by Mann–Whitney test)