Table 2.
Univariate and multivariate analyses of overall survival
| Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| p value | Hazard ratio | 95 % CI | p value | Hazard ratio | 95 % CI | |
| Age, ≧70 years | 0.39 | 0.7 | 0.3–1.6 | |||
| Sex, male | 0.02 | 0.4 | 0.2–0.9 | - | - | - |
| Timing of hepatectomy, synchronous | 0.03 | 2.4 | 1.0–5.0 | - | - | - |
| Distributution, biloblar | <0.01 | 3.4 | 1.5–7.5 | - | - | - |
| Number of tumors, ≧4 | <0.01 | 4.2 | 1.9–9.4 | - | - | - |
| Diameter of tumors, ≧3 | 0.28 | 1.5 | 0.7–3.1 | |||
| Primary site, rectum | 0.22 | 1.6 | 0.8–3.4 | |||
| Primary lymph node metastases, yes | 0.91 | 1.0 | 0.5–2.3 | |||
| Extrahepatic disease, yes | <0.01 | 4.5 | 1.9–11 | - | - | - |
| Neoadjuvant chemotherapy, yes | <0.01 | 3.9 | 1.7–8.5 | - | - | - |
| CRP, ≧2 mg/L | 0.2 | 2.3 | 0.6–7.9 | |||
| Alb, <3.5 g/dL | <0.01 | 6.4 | 1.6–25 | <0.01 | 14.5 | 2.2–92 |
| Lymphocytes, <1000 | 0.55 | 1.3 | 0.6–2.9 | |||
| Neutrophils, ≧6000 | 0.27 | 2.8 | 0.5–17 | |||
| CEA, ≧100 ng/mL | <0.01 | 3.3 | 1.4–8.0 | - | - | - |
| Peritumoral MCs, high | <0.01 | 8.6 | 3.6–20 | <0.01 | 17.3 | 4.8–62 |
| Peritumoral Mφs, high | 0.13 | 2.0 | 0.8–5.0 | |||
| Peritumoral mature DCs, high | 0.34 | 1.7 | 0.6–5.3 | |||
CI confidence interval, CRP C-reactive protein, Alb albumin, CEA carcinoembryonic antigen, MCs mast cells, Mφs macrophages, DCs dendritic cells