Table 4.
Plasma concentration–time profiles of ART with or without CHR (n = 5)
| Ratio | t 1/2 (h) | AUC0–t [mg/(L h)] | Cmax (mg/L) | CLz (L/h/kg) |
|---|---|---|---|---|
| ART alone | 3.62 ± 0.86 | 390.58 ± 32.46 | 51.58 ± 9.47 | 0.013 ± 0.001 |
| ART-CHR-L (1:1) | 3.89 ± 1.93 | 562.20 ± 101.50** | 84.76 ± 19.52* | 0.009 ± 0.002* |
| ART-CHR-M (1:2) | 6.07 ± 2.04*,# | 547.68 ± 76.59** | 85.22 ± 29.56* | 0.009 ± 0.001** |
| ART-CHR-H (1:4) | 3.28 ± 0.77 | 505.21 ± 54.88** | 63.16 ± 16.50 | 0.010 ± 0.001** |
Data are mean values ± SD in five rats
Significantly different from ART alone: * P < 0.05, ** P < 0.01
Significantly difference from ART-CHR-H: # P < 0.05