Table 2.
Cytokine responses and human genes associated with lethal vs. non-lethal filovirus infections in humans.
| Virus | Lethal | Non-Lethal | References |
|---|---|---|---|
| EBOV | TNF-α, IFN-γ, IL-1β, IL-6, IL-8, MCP1, MIP-1α, MIP-1β, IL-10 | [30,31,32,33] | |
| SUDV | IL-1α, IL-6, MCP-1, M-CSF, MIP-1α, Thrombomodulin, ferritin, D-Dimer, AST, BUN, CRE, IL-10, IL-8, NO, HLA-B*67, HLA-B*15 | sCD40L, CA++, IFN-α, HLA-B*07, HLA-B*14 | [36,37] |
| BDBV | IFN-α2, IFN-γ, IL-10 | [38] | |
| TAFV | ND | ND | |
| RESTV | ND | ND | |
| MARV | ND | ND | |
| RAVV | ND | ND | |
| LLOV | N/A | N/A |
N/A, not applicable; ND, not determined.