Table 1.

Known JC agnoprotein binding partners [44]. Function and region of interaction are stated if known.

Host Encoded Interacting Partner	Function	Region of Agnoprotein Required for The Interaction
AP-3 (δ subunit)	Modulates vesicle trafficking, prevents agnoprotein degradation	Residues 1–12
PP2A	Dephosphorylation of JC agnoprotein	Residues 18–36
FEZ1	Facilitates virus release	Unknown
Tubulin	Unknown	Unknown
HP-1α	Nuclear egress of JC virions	N-terminus
p52	Unknown	Unknown
p53	Modulation of the cell cycle	N-terminus
p103	Unknown	Unknown
p112	Unknown	Unknown
p158	Unknown	Unknown
Ku70	Host cell DNA repair	N-terminus
YB-1	Altered host gene expression	Residues 18–36
Virus encoded interacting partner	Function	Region of agnoprotein required for the interaction
JC T-antigen	Repression of JC transcription and DNA replication	N-terminus
JC t-antigen	Disruption of the PP2A – t-antigen interaction	N-terminus
HIV-1 Tat	Inhibition of HIV1 gene expression	Residues 18–54