Figure 2.

Mechanisms of inhibition of virus entry by peptides. Viral entry can be blocked via interaction of peptide with hemagglutinin (HA), commonly interacting with residue of sialic acid. This phenomenon results in the alteration of HA functions, and thus influenza virion cannot be attached to the membrane of a host cell. The second antiviral action of peptides may be carried out intracellularly due to blocking of HA conformation change that commonly leads to open of endosome and dissemination of viral genome.