Table 6.
Plasma, erythrocytes parameters and cognition according to APOE rs7412 and GSTM1 genotype.
| Biomarkers and Cognition | rs7412 | p Value | |||
|---|---|---|---|---|---|
| T/C + T/T (n = 64) | C/C (n = 368) | ||||
| GSTM1+ (n = 26) | GSTM1− (n = 38) | GSTM1+ (n = 175) | GSTM1− (n = 193) | ||
| Plasma | |||||
| Glu (mmol/L) | 5.411 (4.735, 6.087) | 5.994 (5.424, 6.564) | 5.504 (5.234, 5.773) | 5.373 (5.118, 5.627) | 0.145 |
| TG (mmol/L) | 1.662 (1.327, 1.998) | 1.655 (1.373, 1.938) | 1.615 (1.482, 1.749) | 1.480 (1.354, 1.607) | 0.597 |
| TC (mmol/L) | 4.954 (4.617, 5.291) | 4.662 (4.378, 4.946) | 4.909 (4.775, 5.044) | 4.789 (4.662, 4.916) | 0.481 |
| LDL-C (mmol/L) | 3.144 (2.824, 3.465) | 2.899 (2.628, 3.169) | 3.357 (3.229, 3.485) | 3.254 (3.134, 3.375) | 0.537 |
| HDL-C (mmol/L) | 1.386 (1.261, 1.512) | 1.364 (1.258, 1.470) | 1.323 (1.273, 1.373) | 1.322 (1.274, 1.369) | 0.818 |
| MDA (nmol/L) | 7.381 (5.151, 9.611) | 6.018 (4.170, 7.867) | 7.470 (6.611, 8.329) | 6.581 (5.763, 7.400) | 0.766 |
| T-AOC (activity U/L) | 11.289 (9.706, 12.874) | 9.962 (8.649, 11.275) | 11.780 (11.169, 12.390) | 12.023 (11.442, 12.605) | 0.166 |
| Retinol (μg/mL) | 0.715 (0.662, 0.767) | 0.737 (0.693, 0.780) | 0.718 (0.698, 0.739) | 0.728 (0.709, 0.748) | 0.751 |
| α-tocopherol (μg/mL) | 10.769 (9.635, 11.903) | 10.421 (9.483, 11.360) | 10.774 (10.323, 11.225) | 10.297 (9.875, 10.718) | 0.874 |
| Folate (μg/L) | 5.285 (3.749, 6.820) | 6.202 (4.932, 7.472) | 6.216 (5.605, 6.826) | 6.383 (5.812, 6.953) | 0.496 |
| Erythrocyte | |||||
| SOD (U/g Hb) | 32.212 (30.416, 34.007) | 31.362 (29.874, 32.850) | 31.639 (30.947, 32.330) | 31.329 (30.670, 31.988) | 0.674 |
| CAT (U/g Hb) | 2.149 (2.000, 2.298) | 2.436 (2.313, 2.559) | 2.379 (2.322, 2.437) | 2.337 (2.283, 2.392) | 0.002 |
| GSH-PX (U/g Hb) | 29.122 (26.121, 32.123) | 24.438 (21.951, 26.925) | 25.961 (24.806, 27.117) | 26.011 (24.910, 27.113) | 0.028 |
| GST (U/g Hb) | 0.351 (0.291, 0.410) | 0.358 (0.309, 0.408) | 0.332 (0.309, 0.355) | 0.339 (0.317, 0.361) | 0.991 |
| GR (U/g Hb) | 0.615 (0.543, 0.686) | 0.584 (0.525, 0.643) | 0.555 (0.528, 0.582) | 0.543 (0.517, 0.569) | 0.713 |
| Cognition | |||||
| Moca Score | 26.260 (25.197, 27.322) | 25.759 (24.843, 26.675) | 26.384 (25.959, 26.809) | 26.540 (26.140, 26.941) | 0.399 |
General linear model used. Data are presented as the mean (95% CI). For plasma Glu, TG, TC, LDL-C, and HDL-C data analysis, factors including gender, age, BMI, smoking, physical activity were adjusted. For erythrocytes antioxidant biomarkers and plasma folate, retinol, and α-tocopherol data analysis, factors including gender, age, BMI, smoking, and antioxidant supplementation were adjusted. For cognition (MoCA score) analysis, factors including gender, age, BMI, physical activity, education level, living condition, reading time per day, and antioxidant supplementation were adjusted. p value < 0.05 was considered as significant.