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Schematic representation of possible mechanisms of PknB_PASTA-mediated growth inhibition. (a) In the TMP strain the overexpressed PknB_PASTA competes with native PknB for peptidoglycan ligands and interferes with PknB-mediated signalling. (b) Overexpressed PknB_PASTA binds penicillin-binding proteins and dysregulates peptidoglycan polymerization. (c) Overexpressed PknB_PASTA binds to peptidoglycan and destabilizes its structure. PGS, peptidoglycan synthesis complex.
