Figure 1.

(a) Chemical structures of 2-OH-1,4-NQ derivatives tested in this study. Asterisk refers to the fact that molecule 010-G has a chloride (and not hydroxyl) at position 2. (b) Chemical structure of 2-(trans-4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone (atovaquone). (c) Predicted logS values (aqueous solubility) of the different drugs versus their molecular weight (g mol⁻¹). The four molecules selected for in vitro testing (figure 4) and for mouse experiments (figure 6) are indicated above their symbol (filled squares). Atov, atovaquone.