Table 1.
In vitro and biological activity of 2-OH-1,4-NQ compounds against HpThyX and H. pylori, respectively.
| minimal inhibitory concentration (MIC) |
|||
|---|---|---|---|
| molecule | inhibition against ThyX (% remaining activity relative to control) | strain 26695 (µg ml−1) (µM) | strain SS1 (µg ml−1) (µM) |
| 007-A (C8C1) | 38.5 | 10 (33.98) | 10 (33.98) |
| 007-B | 60.2 | 10 (26.68) | 10 (26.68) |
| 007-C | 62.5 | 5 (13.01) | 5 (13.01) |
| 007-D | 45.7 | ≥20 (62.03) | 20 (62.03) |
| 007-E | 66.3 | 10 (35.42) | 10 (35.42) |
| 007-F | 60.6 | 5 (15.06) | 10 (15.06) |
| 007-G | 61.8 | 20 (56.16) | 5 (14.04) |
| 010-A | 49.5 | 10 (33.48) | 5 (16.74) |
| 010-B | 74.3 | 10 (33.30) | 10 (33.30) |
| 010-C | 76.4 | 10 (39.34) | 10 (39.34) |
| 010-D | 36.4 | 10 (37.00) | 10 (37.00) |
| 010-E | 77.7 | 5 (14.27) | 5 (14.27) |
| 010-F | 74.5 | 10 (31.58) | 5 (15.79) |
| 010-G | 21.1 | 0.625 (2.07) | 0.625 (2.07) |
| 010-H | 57.8 | 20 (64.45) | 10 (32.23) |
| 010-I | 64.3 | 10 (43.42) | 10 (43.42) |
| 010-J | 49.7 | 2.5 (8.49) | 2.5 (8.49) |
| 010-K | 75.1 | 20 (61.67) | 10 (30.84) |