Table 2.

HER2 expression in gastric cancer: analysing studies with patients from different parts of the world

Study	Year	Patients’ place of origin	Number of patients	HER2 positive rate (%)	Association with clinicopathological features
Bang YJ [6]	2010	ToGA trial (Multicenter)	3,665	16.6	Topography (GEJ)
					Intestinal-type
Begnami MD [19]	2011	Brazil (Single center)	221	8.0	Intestinal-type
					Low-grade
Cruz-Reyes C [45]	2013	Mexico (Single center)	269	3.7	Intestinal-type
Cho J [32]	2013	South Korea (Single center)	2,798	7.3	Older age
					Male gender
					Intestinal-type
					Upper-third stomach
					Higher lymph node stage
					Advanced staging
Shan L [17]	2013	China (Single center)	1,463	9.8	Topography (GEJ)
					Intestinal-type
					Low-grade
Matsusaka S [35]	2015	Japan (Multicenter)	1,461	15.6	Intestinal-type
					Hepatic metastasis
					Absence of peritoneal metastasis
Cappellesso R [34]	2015	Europe (Multicenter)	1,040	11.0	Intestinal-type
					Low-grade
Laboissiere RS	2015	Brazil (Single Center)	124	10.5	Intestinal-type
					Low-grade
					Lymphovascular invasion

GEJ gastroesophageal junction