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. 2015 Nov 4;5:60. doi: 10.1186/s13578-015-0051-9

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© Guan and Kao. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Summary of PML functions in diseases. PML plays pivotal roles in the indicated conditions including anti-inflammatory responses, metabolism, stem cell maintenance, circadian rhythms, aging and unfolded protein responses. PML protein exerts its tumor suppressive function by regulating the cell cycle, apoptosis, senescence, migration, angiogenesis, and DNA repair pathways