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. 2015 Sep 30;16(10):23572–23586. doi: 10.3390/ijms161023572

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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The pathogenicity of wild-type and conditional mutant MTB strains. The wild-type MTB H37Rv bacteria showed the highest infection capacity (approximately 10 bacteria per macrophage) (A), while the capacity of the mutant to infect macrophages was gradually increased with the concentration of pristinamycin and the period of induction (B). The experiments were repeated for three times, and results were expressed as mean ± SD. Results were compared using one-way ANOVA method (*** p < 0.001).