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. 2015 Oct 14;16(10):24295–24301. doi: 10.3390/ijms161024295

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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(a) The distribution of nucleotide substitution types and their proportions of NDs in comparison with non-NDs; (b) The amino-acid substitution spectrum of disease-causing missense mutations in NDs and non-NDs.

(a) The distribution of nucleotide substitution types and their proportions of NDs in comparison with non-NDs; (b) The amino-acid substitution spectrum of disease-causing missense mutations in NDs and non-NDs.