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Folic acid raises and zebularine lowers DNMT activity, without altering cell viability. N2a-APP cells were incubated as described in Figure 1. (A) DNMT activity in nuclear extracts; (B) Cell viability based on Alamar blue assay. The plotted values are mean ± SEM values for 3 experiments. * p < 0.05 compared with 2.8 μmol/L. # p < 0.05 compared with 10 μmol/L. ** p < 0.05 compared with vehicle at the same folic acid concentration.
