Table 1.

Studies on lifestyle interventions in non-alcoholic fatty liver disease (NAFLD).

Intervention	Findings	Reference
Weight loss ≥5% of initial body weight	Significant reduction in systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol, triglycerides, alanine aminotransferase (ALT), aspartate aminotransferase, and γ-glutamyl transferase in the adherent group (weight loss ≥5% of initial body weight)	[13]
Weight loss (≥7%)	Weight loss is safe and improves liver histology and cardiometabolic profile, but it is only achieved in <50% of patients	[16]
Increasing or maintaining the level of physical activity in 150 min/week or more	Greater improvement in levels of liver enzymes, independently of changes in weight	[18]
Complete a regular exercise program	ALT normalization	[19]
Training exercises for 4 weeks	Reduction in liver lipids in obese patients even in the absence of changes in body weight	[20]
Intensive lifestyle interventions	Intensive lifestyle interventions were more effective than the prescription of dietary standard, both in weight loss and in liver enzymes	[23]
Review of the current management of pediatric NAFLD	Lifestyle interventions should be the first line treatment for pediatric NAFLD. Vitamin E could be considered for those with non-alcoholic steatohepatitis (NASH) demonstrated by biopsy or those at risk for NASH where the first line therapy has failed. Other therapies require large RCTs in pediatric population	[5]