Figure 3.

Factors that alter regenerative capacity upon aging. Multiple cell-intrinsic and cell-extrinsic factors are associated with the decline of regenerative capacity during aging (left). These impact on regenerative cell types by altering key cellular processes (middle), leading to various negative outcomes that result in regeneration impairment (right). * Cell senescence can be considered an intrinsic and, potentially, extrinsic factor (see Section 4).