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. 2015 Oct 23;16(10):25502–25515. doi: 10.3390/ijms161025502

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Concentration of humanized anti-TLR4 antibody Fab with effective inhibitory effect on lipopolysaccharides (LPS)-stimulated macrophages. (A,B) Effects of different concentration of the antibody on inhibition of TNF-α (A) and IFN-β (B) expression induced by LPS (1 µg/mL) in mouse macrophages; (C,D) Effects of different concentration of the antibody on inhibition of TNF-α (C) and IFN-β (D) expression induced by LPS (100 ng/mL) in mouse macrophages; (E,F) Effects of different concentration of the antibody on inhibition of TNF-α (E) and IFN-β (F) expression induced by LPS (10 ng/mL) in mouse macrophages. The expressions of TNF-α, IFN-β were measured by Q-PCR. L: LPS; A: humanized anti-TLR4 antibody. Data are shown as mean ± SD of pooled results of three independent experiments (* p < 0.05 compared to LPS group).

Concentration of humanized anti-TLR4 antibody Fab with effective inhibitory effect on lipopolysaccharides (LPS)-stimulated macrophages. (A,B) Effects of different concentration of the antibody on inhibition of TNF-α (A) and IFN-β (B) expression induced by LPS (1 µg/mL) in mouse macrophages; (C,D) Effects of different concentration of the antibody on inhibition of TNF-α (C) and IFN-β (D) expression induced by LPS (100 ng/mL) in mouse macrophages; (E,F) Effects of different concentration of the antibody on inhibition of TNF-α (E) and IFN-β (F) expression induced by LPS (10 ng/mL) in mouse macrophages. The expressions of TNF-α, IFN-β were measured by Q-PCR. L: LPS; A: humanized anti-TLR4 antibody. Data are shown as mean ± SD of pooled results of three independent experiments (* p < 0.05 compared to LPS group).