Fig. 3.

miR-377 expression is inversely correlated with that of BCL-xL. a Correlation of BCL-xL and miR-377 expression in a panel of lymphoid B-cell lines. BCL-xL and miR-377 RNA expression was normalized to that of lymphocytes isolated from healthy donors. b miR-377 expression is inversely correlated with that of BCL-xL in 43 CLL patients as determined by RT-PCR. Spearman correlation (r) and P values are shown. c CLL patients with high BCL-xL levels show decreased levels of miR-377 expression as determined by RT-PCR. Each dot represents one CLL patient. d CLL patients with advanced tumor stage have significantly lower miR-377 and higher BCL-xL expression compared to CLL patients with early tumor stage that have high miR-377 and lower BCL-xL expression. e miR-377 expression in CLL patients who had received a diverse array of chemotherapy regimens versus untreated CLL patients