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Specific activity screen of histidine mutants and WT pPAF-AH for each of the four stereoisomers of soman (GD). Each bar represents the average of three independent experiments. Mock expressions were run in parallel, and their average value was subtracted from each of the experimental bars. A one-way ANOVA followed by Bonferroni’s multiple comparison test determined a significant difference (P < 0.001) between W298H and all other mutants.
