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. 2015 Feb 13;6(6):695–703. doi: 10.1111/1759-7714.12239

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© 2015 The Authors. Thoracic Cancer published by China Lung Oncology Group and Wiley Publishing Asia Pty Ltd.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Impact of lapatinib on the estrogen receptor (ER)α and human epidermal growth factor receptor (HER)2 pathways in the sensitive strain cell BT474. (a) & (b) The of phosphorylation of HER2, protein kinase B (AKT), and extracellular-signal-related-kinase (ERK) of BT474 were reduced with 1 μM lapatinib, but the ER pathway was activated, which was manifested by the increased expression of ERα, PR, and forkhead-box (FOX)O3a at messenger ribonucleic acid (mRNA) and protein level (P < 0.05). Lap, lapatinib. , dimethyl sulfoxide (DMSO); , Lap (0.5 μM); , Lap (1 μM).

Inline graphic — Impact of lapatinib on the estrogen receptor (ER)α and human epidermal growth factor receptor (HER)2 pathways in the sensitive strain cell BT474. (a) & (b) The of phosphorylation of HER2, protein kinase B (AKT), and extracellular-signal-related-kinase (ERK) of BT474 were reduced with 1 μM lapatinib, but the ER pathway was activated, which was manifested by the increased expression of ERα, PR, and forkhead-box (FOX)O3a at messenger ribonucleic acid (mRNA) and protein level (P < 0.05). Lap, lapatinib. , dimethyl sulfoxide (DMSO); , Lap (0.5 μM); , Lap (1 μM).