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. 2015 Mar 18;6(6):715–721. doi: 10.1111/1759-7714.12246

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© 2015 The Authors. Thoracic Cancer published by China Lung Oncology Group and Wiley Publishing Asia Pty Ltd.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Overexpression of 14-3-3 σ inhibited the proliferation and tumorigenicity of squamous cell carcinoma (SqCC). (a) Immunoblot of untransfected H520 cells (parental H520), H520 cells transfected with empty vector (H520-vector), and H520 cells transfected with 14-3-3 σ (H520-14-3-3 σ). Blots were probed with monoclonal mouse β-actin antibody to control for protein loading and transfer. (b) The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay of H520 cell clones in (a), except for parental H520. Means and 95% confidence intervals (error bars, calculated from the 8 replicates) are shown. (c) Tumors in nude mice inoculated with H520 colonies stably transfected with vector or 14-3-3 σ. , H520-14-3-3 σ; , H520-vector.

Inline graphic — Overexpression of 14-3-3 σ inhibited the proliferation and tumorigenicity of squamous cell carcinoma (SqCC). (a) Immunoblot of untransfected H520 cells (parental H520), H520 cells transfected with empty vector (H520-vector), and H520 cells transfected with 14-3-3 σ (H520-14-3-3 σ). Blots were probed with monoclonal mouse β-actin antibody to control for protein loading and transfer. (b) The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay of H520 cell clones in (a), except for parental H520. Means and 95% confidence intervals (error bars, calculated from the 8 replicates) are shown. (c) Tumors in nude mice inoculated with H520 colonies stably transfected with vector or 14-3-3 σ. , H520-14-3-3 σ; , H520-vector.