Table 3.
Toxicity and side effects
| Toxicity type | IP (n = 30) | EP (n = 32) | P value | ||
|---|---|---|---|---|---|
| Grade1-2 | Grade3-4 (%) | Grade1-2 | Grade3-4 (%) | ||
| Neutropenia | 10 | 16 (53.3) | 8 | 23 (71.9) | 0.057 |
| Leukopenia | 13 | 13 (43.3) | 12 | 17 (53.1) | 0.271 |
| Anemia | 18 | 9 (30.0) | 18 | 10 (31.3) | 0.114 |
| Thrombocytopenia | 5 | 2 (6.7) | 16 | 6 (18.8) | 0.035 |
| Nausea/vomiting | 23 | 4 (13.3) | 23 | 3 (9.4) | 0.237 |
| Diarrhea | 16 | 5 (16.7) | 5 | 0 (0.0) | 0.008 |
| Constipation | 8 | 3 (10.0) | 7 | 3 (9.4) | 0.167 |
| Infection | 5 | 1 (3.3) | 2 | 1 (3.1) | 0.076 |
| Alopecia | 3 | 0 (0.0) | 4 | 0 (0) | 0.107 |
| Fatigue | 24 | 3 (10.0) | 23 | 4 (12.5) | 0.236 |
| Hepatic dysfunction | 12 | 1 (3.3) | 6 | 1 (3.1) | 0.191 |
EP, etoposide plus cisplatin; IP, irinotecan plus cisplatin.