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. 2015 Oct 5;3(10):e12537. doi: 10.14814/phy2.12537

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Dicer exon 24 excision resulted in impaired miRNA biogenesis in E18.5 FoxD1^GC;Dicer^fl/fl kidneys. (A) To evaluate the excision of Dicer exon 24, quantitative real-time PCR was carried out and revealed a significant decrease in Dicer exon 24, but not in exons 21 and 23 transcripts (n = 6, ***P < 0.001). (B) LNA SISH revealed reduced miR-17 expression within the FoxD1^GC;Dicer^fl/fl medullary interstitium (MI), thereby indicating impaired miRNA biogenesis as a consequence of loss of Dicer activity.