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. 2015 Oct 14;3(10):e12568. doi: 10.14814/phy2.12568

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Venn diagram showing the distribution of genes that responded to BPS and WEX exercises. (A) 617 genes responded solely to BPS exercise while 133 genes were differentially expressed only in WEX. 191 genes were differentially expressed both in BPS and WEX compared to the CON group. (B) Among the 191 genes that were differentially expressed both in BPS and WEX, 51 were up-regulated and 51 were down-regulated in both exercise groups compared to the control. The behavior of the remaining 89 genes depended on the exercise imposed. While they were up-regulated in the BPS group, the same set of genes was down-regulated in the WEX group. The up-regulated gene list was enriched for terms associated with skeletal system development. The down-regulated gene list was enriched for immune system processes and the remaining 89 genes were involved in muscle contraction. CON, Control; BPS, Bipedal Stance; WEX, Wheel Exercise.