Table 4.
Canonical pathways enriched for differentially expressed transcripts in BPS and WEX rats. Enrichment was determined using IPA. The P-value was calculated using the Fisher’s exact test. The ratio gives an indication of the number of differentially expressed transcripts compared to the total number of genes in the dataset that correspond to a canonical pathway
| BPS | WEX | ||||||
|---|---|---|---|---|---|---|---|
| No | Canonical pathway | P-value | Ratio | No | Canonical pathway | P-value | Ratio |
| 1 | Oxidative phosphorylation | 1.66 * 10−31 | 40/86 (0.465) | 1 | Epithelial adherens junction signaling | 1.07 * 10−04 | 10/136 (0.074) |
| 2 | Mitochondrial dysfunction | 2.21 * 10−25 | 44/144 (0.306) | 2 | Calcium signaling | 1.24 * 10−04 | 11/166 (0.066) |
| 3 | Calcium signaling | 8.83 * 10−10 | 28/166 (0.169) | 3 | ILK signaling | 1.62 * 10−04 | 11/171 (0.064) |
| 4 | Cellular effects of sildenafil | 1.87 * 10−08 | 22/123 (0.179) | 4 | Cellular effects of sildenafil | 2.45 * 10−04 | 9/123 (0.073) |
| 5 | ILK Signaling | 3.27 * 10−08 | 26/171 (0.152) | 5 | Remodeling of epithelial adherens junctions | 5.67 * 10−04 | 6/61 (0.098) |