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System A uptake activity following treatment with TNF-α and Erk/p38 MAPK antagonists. Na+-dependent MeAIB uptake was measured in primary human trophoblasts following treatment with pharmacological antagonists U0126 (Erk inhibitor, 0.1 μmol/L) or SB203580 (p38 inhibitor, 10 μmol/L) MAPK, 30 min prior to exposure to TNF-α (10 pg/mL) for 24 h. Data are presented as mean + SEM, n = 9. *P < 0.05, **P < 0.01. Cnt, control; TNF-α, tumor necrosis factor-alpha.
