Table 3.

Regional comparison of gray matter volume between patients with on-line game addiction (POGA), pro-gamer, and healthy comparison subjects.

Talairach			κ E	t	p value	Regions
x	y	z
Patients with on-line game addiction vs Healthy comparison subjects
Patients with on-line game addiction > Healthy comparison subjects
−20	−29	2	1527	4.25	puncorrected < 0.0001	left thalamus
−37	−60	35	602	4.60	puncorrected < 0.0001	left parietal angular gyrus BA39
Patients with on-line game addiction < Healthy comparison subjects
59	−38	−19	2421	6.45	PFDR-corr = 0.001	right inferior temporal gyrus, BA 20
48	−71	−5	1146	5.75	PFDR-corr = 0.001	right middle occipital gyrus, BA 19
−44	−76	−4	2067	4.15	PFDR-corr = 0.002	left inferior occipital gyrus, BA 19
−47	−55	−10	703	4.06	PFDR-corr = 0.002	left temporal fusiform gyrus, BA 37
−57	−27	−21	1056	3.94	PFDR-corr = 0.002	left inferior temporal gyrus, BA20
Pro-gamers vs healthy comparison subjects
Pro-gamers > healthy comparison subjects
−18	11	35	461	6.83	PFDR-corr = 0.02	left cingulate gyrus, BA 32
−3	5	31	1247	4.57	puncorrected < 0.0001	left cingulate gyrus, BA 24
23	−8	43	743	4.21	puncorrected < 0.0001	right middle frontal gyrus, BA 6
Pro-gamers < healthy comparison subjects
−46	−82	−1	4123	7.90	PFDR-corr < 0.001	left middle occipital gyrus, BA 19
−62	−34	−10	2486	4.94	PFDR-corr = 0.003	left middle temporal gyrus, BA21
50	−74	−1	3580	7.35	PFDR-corr < 0.001	right inferior temporal gyrus, BA 19
Pro-gamer vs Patients with on-line game addiction
Pro-gamer > Patients with on-line game addiction
−3	6	31	3310	5.09	PFDR-corr = 0.02	left cingulate gyrus, BA 24
Pro-gamer < Patients with on-line game addiction
−18	−26	11	2550	4.67	puncorrected < 0.0001	left thalamus

P_FDR-corr: corrected FDR<0.05, p_uncorrected: uncorrected.