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A summary of important signaling pathways affected by MDA-9/Syntenin that impact cancer progression, particularly motility, invasion and angiogenesis.
ECM: Extracellular matrix; FAK: Focal adhesion kinase; GSK3β: Glycogen synthase kinase 3β; HIF-1α: Hypoxia inducible factor-1α; IGFBP-2: Insulin-like growth factor binding protein – 2; IKK: IκB-kinase; MDA-9: Melanoma differentiation-associated gene – 9; PKCα: Protein kinase C – α.
