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. Author manuscript; available in PMC: 2015 Nov 4.
Published in final edited form as: Adv Exp Med Biol. 2014;818:127–153. doi: 10.1007/978-1-4471-6458-6_6

Fig. 6.1. Schematic representation of MDA-7/IL-24 protein with predicted and established domains and protein modification sites illustrated.

Fig. 6.1

MDA-7/IL-24 contains an IL-10 signature sequence between amino acids 101 and 121. The MDA-7/IL-24 signal peptide is cleaved to allow secretion of MDA-7/IL-24 protein. MDA-7/IL-24 is glycosylated at three sites at amino acid 85, 99 and 126. Protein kinase C consensus phosphorylation sites are present at amino acid 88, 133 and 161, while Casein kinase II (CKII) consensus phosphorylation sites are present at amino acid 101, 111 and 161. Numbers indicate amino acids. Not drawn to scale (Figure modified from Sauane et al. [81], Copyright 2003, with permission from Elsevier)