Table 4. Stratification analysis for sex between Clear and CHB in male patients.
| Polymorphisms | Allele | Clear (n = 174) | CHB (n = 408) | Clear vs.CHB | |
|---|---|---|---|---|---|
| P | OR (95%CI) | ||||
| rs11866328 | TT | 11 (0.06) | 11 (0.03) | ||
| TG | 56 (0.32) | 132 (0.32) | 0.236 | 2.020 (0.591–6.907) a | |
| GG | 107 (0.62) | 265 (0.65) | 0.278 | 1.838 (0.612–5.515) b | |
| GG+TG | 163 (0.94) | 397 (0.97) | 0.247 | 1.878 (0.646–5.640) c | |
| T | 78 (0.22) | 154 (0.19) | |||
| G | 270 (0.78) | 662 (0.81) | 0.268 | 1.231(0.852–1.781) d | |
| rs10845858 | AA | 31 (0.18) | 72 (0.18) | ||
| AG | 91(0.52) | 214 (0.52) | 0.888 | 1.047 (0.553–1.983) a | |
| GG | 52 (0.30) | 122 (0.30) | 0.897 | 0.955 (0.474–1.924) b | |
| AG+GG | 143 (0.82) | 336 (0.82) | 0.988 | 1.005 (0.562–1.796) c | |
| A | 153 (0.44) | 358 (0.44) | |||
| G | 195 (0.56) | 458 (0.56) | 0.933 | 0.987 (0.731–1.334) d | |
| rs1041236 | TT | 96 (0.55) | 202 (0.49) | ||
| TC | 64 (0.37) | 170 (0.42) | 0.918 | 1.024 (0.649–1.618) a | |
| CC | 14 (0.08) | 36 (0.09) | 0.879 | 0.937 (0.405–2.168) b | |
| TC+CC | 78 (0.45) | 206 (0.51) | 0.948 | 1.014 (0.661–1.557) c | |
| T | 256 (0.74) | 574 (0.70) | |||
| C | 92 (0.26) | 242 (0.30) | 0.952 | 0.990 (0.699–1.385) d | |
| rs2013562 | CC | 43 (0.25) | 81 (0.20) | ||
| CT | 86 (0.49) | 197 (0.48) | 0.171 | 1.492 (0.842–2.647) a | |
| TT | 45 (0.26) | 130 (0.32) | 0.14 | 1.705 (0.839–3.465) b | |
| CT+TT | 131 (0.75) | 327 (0.80) | 0.145 | 1.487 (0.872–2.536) c | |
| C | 172 (0.49) | 359 (0.44) | |||
| T | 176 (0.51) | 457 (0.56) | 0.211 | 1.214 (0.896–1.645) d | |
| rs7861010 | AA | 10 (0.06) | 31 (0.08) | ||
| AG | 66 (0.38) | 148 (0.36) | 0.083 | 0.421 (0.158–1.120) a | |
| GG | 98 (0.56) | 229 (0.56) | 0.111 | 0.486 (0.200–1.181) b | |
| AG+GG | 164 (0.94) | 377 (0.92) | 0.078 | 0.467 (0.200–1.089) c | |
| A | 86 (0.25) | 210 (0.26) | |||
| G | 262 (0.75) | 606 (0.74) | 0.996 | - d | |
| rs12206945 | GG | 10 (0.06) | 34 (0.08) | ||
| GA | 61 (0.35) | 131 (0.32) | 0.32 | 0.591 (0.210–1.665) a | |
| AA | 103 (0.59) | 243 (0.60) | 0.492 | 0.713 (0.272–1.870) b | |
| GA+AA | 164 (0.94) | 374 (0.92) | 0.383 | 0.663 (0.263–1.669) c | |
| G | 81 (0.23) | 199 (0.24) | |||
| A | 267 (0.77) | 616 (0.76) | 0.389 | 0.852 (0.593–1.226) d | |
| rs10485138 | TT | 7 (0.04) | 11 (0.03) | ||
| TC | 46 (0.26) | 108 (0.26) | 0.943 | 1.054 (0.246–4.513) a | |
| CC | 121 (0.70) | 289 (0.71) | 0.814 | 1.165 (0.327–4.151) b | |
| TC+CC | 167 (0.96) | 397 (0.49) | 0.832 | 1.140 (0.339–3.837) c | |
| T | 60 (0.17) | 130 (0.16) | |||
| C | 288 (0.83) | 686 (0.84) | 0.717 | 1.078 (0.718–1.620) d | |
| rs6909880 | GG | 17 (0.10) | 26 (0.06) | ||
| GT | 71 (0.41) | 147 (0.36) | 0.253 | 1.726 (0.677–4.405) a | |
| TT | 86 (0.49) | 235 (0.58) | 0.988 | 1.007 (0.405–2.504) b | |
| GT+TT | 157 (0.90) | 382 (0.47) | 0.627 | 1.229 (0.536–2.818) c | |
| G | 105 (0.30) | 199 (0.24) | |||
| T | 243 (0.70) | 617 (0.76) | 0.564 | 1.103 (0.791–1.537) d | |
SNP: single nucleotide polymorphisms, Clear: spontaneously recovered individuals with history of HBV infection, CHB: chronic hepatitis B patients. P values, ORs and 95% CIs were calculated by multiple logistic regression adjusting for age; - means differences could not be detected.
a means additive model: the first genotype/the second genotype
bmeans additive model: the first genotype/the third genotype
cmeans recessive model: the first genotype/the second +the third genotype
dmeans allele model.