Table 5. Stratification analysis for sex between Clear and CHB in female patients.
Polymorphisms | Allele | Clear (n = 208) | CHB (n = 85) | Clear vs.CHB | ||
---|---|---|---|---|---|---|
P | OR (95%CI) | |||||
rs11866328 | TT | 11 (0.05) | 6 (0.07) | |||
TG | 67 (0.32) | 27 (0.32) | 0.911 | 1.166 (0.080–17.071) a | ||
GG | 130 (0.63) | 52 (0.61) | 0.334 | 0.441 (0.084–2.321) b | ||
TG+GG | 197 (0.95) | 79 (0.93) | 0.410 | 0.502 (0.097–2.590) c | ||
T | 89 (0.21) | 39 (0.23) | ||||
G | 327 (0.79) | 131 (0.77) | 0.468 | 0.807 (0.453–1.439) d | ||
rs10845858 | AA | 27 (0.13) | 15 (0.18) | |||
AG | 115 (0.55) | 40 (0.47) | 0.108 | 0.430 (0.153–1.204) a | ||
GG | 66 (0.32) | 30 (0.35) | 0.486 | 0.648 (0.191–2.195) b | ||
AG+GG | 181 (0.44) | 70 (0.41) | 0.115 | 0.477 (0.190–1.198) c | ||
A | 169 (0.41) | 70 (0.41) | ||||
G | 247 (0.59) | 100 (0.59) | 0.777 | 0.932 (0.573–1.516) d | ||
rs1041236 | TT | 112 (0.54) | 51 (0.60) | |||
TC | 90 (0.43) | 28 (0.33) | 0.409 | 0.639 (0.221–1.849) a | ||
CC | 6 (0.03) | 6 (0.07) | 0.047 | 0.099 (0.0010–0.968) b | ||
TC+CC | 96 (0.46) | 34 (0.40) | 0.978 | 0.987 (0.380–2.562) c | ||
T | 314 (0.75) | 130 (0.76) | ||||
C | 102 (0.25) | 40 (0.24) | 0.492 | 1.304 (0.613–2.770) d | ||
rs2013562 | CC | 38 (0.18) | 17 (0.2) | |||
CT | 101 (0.49) | 49 (0.58) | 0.363 | 1.594 (0.583–4.357) a | ||
TT | 69 (0.33) | 19 (0.22) | 0.991 | 0.990 (0.173–5.673) b | ||
CT+TT | 170 (0.82) | 68 (0.4) | 0.597 | 1.308 (0.483–3.544) c | ||
C | 177 (0.43) | 83 (0.49) | ||||
T | 239 (0.57) | 87 (0.51) | 0.421 | 0.819 (0.502–1.334) d | ||
rs7861010 | AA | 20 (0.10) | 1 (0.01) | |||
AG | 82 (0.39) | 55 (0.65) | 0.994 | - a | ||
GG | 106 (0.51) | 29 (0.34) | 0.992 | - b | ||
AG+GG | 188 (0.90) | 84 (0.99) | 0.994 | - c | ||
A | 122 (0.29) | 57 (0.34) | ||||
G | 294 (0.71) | 11 (0.66) | 0.836 | 1.078 (0.530–2.192) d | ||
rs12206945 | GG | 16 (0.08) | 4 (0.05) | |||
GA | 83 (0.40) | 54 (0.63) | 0.382 | 2.185 (0.379–12.584) a | ||
AA | 109 (0.52) | 27 (0.32) | 0.620 | 1.624 (0.239–11.051) b | ||
GA+AA | 192 (0.92) | 81 (0.95) | 0.502 | 1.773 (0.334–9.418) c | ||
G | 115 (0.28) | 62 (0.36) | ||||
A | 301 (0.72) | 108 (0.64) | 0.349 | 0.773 (0.451–1.324) d | ||
rs10485138 | TT | 8 (0.04) | 3 (0.04) | |||
TC | 74 (0.36) | 47 (0.55) | 0.385 | 0.232 (0.009–6.243) a | ||
CC | 126 (0.60) | 35 (0.41) | 0.187 | 0.096 (0.003–3.110) b | ||
TC+CC | 200 (0.96) | 82 (0.96) | 0.239 | 0.161 (0.008–3.369) c | ||
T | 90 (0.22) | 53 (0.31) | ||||
C | 326 (0.78) | 117 (0.69) | 0.005 | 0.445 (0.253–0.784) d | ||
rs6909880 | GG | 21 (0.10) | 6 (0.07) | |||
GT | 81 (0.39) | 39 (0.46) | 0.804 | 1.177 (0.326–4.246) a | ||
TT | 106 (0.51) | 40 (0.47) | 0.636 | 0.720 (0.185–2.808) b | ||
GT+TT | 187 (0.90) | 79 (0.93) | 0.838 | 0.888 (0.286–2.755) c | ||
G | 123 (0.30) | 51 (0.30) | ||||
T | 293 (0.70) | 119 (0.70) | 0.220 | 0.728 (0.439–1.209) d |
SNP: single nucleotide polymorphisms, Clear: spontaneously recovered individuals with history of HBV infection, CHB: chronic hepatitis B patients. P values, ORs and 95% CIs were calculated by multiple logistic regression adjusting for age; - means differences could not be detected.
a means additive model: the first genotype/the second genotype
bmeans additive model: the first genotype/the third genotype
cmeans recessive model: the first genotype/the second +the third genotype
dmeans allele model.