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. 2015 Nov 4;10(11):e0142303. doi: 10.1371/journal.pone.0142303

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© 2015 Helmy et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — Panel A, the total severity score for tubular damage obtained from H&E stained kidney sections (×400): score 0: normal histology, score 1: tubular cell swelling, brush border loss with up to 1/3 of the tubular profile showing nuclear loss, score 2: from 1/3 to 2/3 of the tubular profile showing nuclear loss, and score 3: more than 2/3 of the tubular profile showing nuclear loss. Shown also in panel A the graphical presentation of the total severity score for tubular necrosis of different treated groups. *, ⁺, ^# and ^π denote significant difference (P<0.05) vs. control, cisplatin, cisplatin+pioglitazone and cisplatin+fenofibratevalues, respectively. Panel B, hematoxylin and eosin stained photomicrographs (×100 and ×400) of kidneys obtained from rats treated with saline (control, image a), cisplatin (5mg/kg, i.p., image b), cisplatin+pioglitazone (2.5 mg/kg/day, orally, image c), cisplatin+fenofibrate (100 mg/kg/day, orally, image d), cisplatin+pioglitazone+fenofibrate (e), cisplatin+pioglitazone+GW9662 (1 mg/kg/day, i.p, image f), cisplatin+fenofibrate+GW6471 (1 mg/kg/day, i.p, image g) and cisplatin+thalidomide (12.5 mg/kg/day, i.p, image h). The black arrow shows glomerular atrophy whereas white arrows point to acute tubular necrosis, marked dilation of proximal convoluted tubules with vacuolation.