Fig 5. Immunohistochemical PPAR-α receptor expression in renal cortical glomeruli and medullary tubules obtained from rats treated with saline (control), cisplatin (Cis, 5mg/kg, i.p.), cisplatin+pioglitazone (PIO, 2.5 mg/kg/day, orally), cisplatin+fenofibrate (Feno, 100 mg/kg/day, orally), cisplatin+pioglitazone+fenofibrate, cisplatin+pioglitazone+GW9662 (1 mg/kg/day, i.p), cisplatin+fenofibrate+GW6471 (1 mg/kg/day, i.p) and cisplatin+thalidomide (Thalid, 12.5 mg/kg/day, i.p).

All drugs were administered 2 days before cisplatin injection and continued for 3 days thereafter. Values are means±S.E.M. of 8 observations.*, ⁺, ^# and ^π denote significant difference (P<0.05) vs. control, cisplatin, cisplatin+pioglitazone and cisplatin+fenofibratevalues, respectively. Representative images of immunostained tissues are also shown (×400, A, control; B, cisplatin; C, cisplatin + pioglitazone; D, cisplatin + fenofibrate; E, cisplatin + pioglitazone + fenofibrate; F, cisplatin + pioglitazone + GW9662; G, cisplatin + fenofibrate + GW6471; H, cisplatin + thalidomide).