Fig 4. (A) Vascular density (factor VIII), B) endothelial proliferation (BrdU labeling index), and (C) mural vascular cell proliferation (BrdU labeling index) in the tumor-adjacent prostate tissue (TINT) and in controls, a; significantly different than controls, b; large G tumors significantly different than small G tumors, c; significantly different than corresponding tumor at day 7, and d; significantly different than corresponding tumor at day 10, P<0.05, n = 5–13. (D) Scatterplot of the BrdU-labeling index in mural vascular cells plotted against tumor size. MatLyLu tumors (X) were considerably more effective than the other tumor types (AT-1; Δ and G; O) in stimulating growth of larger blood vessels in the tumor-bearing organ. Correlation coefficients are given in results section. (E) Representative sections from the ventral prostate lobe of Dunning tumor-bearing and control rats stained to visualize BrdU-labeled cells (Brown, 200X magnifications, T; tumors). Detail (400X magnifications) of vascular (endothelial cell marked with arrow, mural vascular cell marked with arrowhead) BrdU labeling in a 10 day MatLyLu tumor. (F) Representative sections from the ventral prostate lobe of Dunning tumor-bearing and control rats injected with pimonidazole to label hypoxic tissue (brown, 100x magnification, T; tumor).