Table 4. Comparison between AT-1 and MatLyLu tumors of similar sizes.
| AT-1 | MatLyLu | |
|---|---|---|
| Cells injected (n) | 2000 | 2000 |
| Animals (n) | 8 | 7 |
| Days | 10 | 10 |
| Tumor weight (mg) | 97 +/- 39 | 90 +/- 47 |
| Tumor cell proliferation BrdU (%) | 29 +/- 4.5 | 42 +/- 7.3* |
| CD68 density in tumor (%) | 4.3 +/- 0.3 | 9.9 +/- 1.5* |
| CD68 density in TINT (%) | 1.2 +/- 0.5 | 3.3 +/- 1.4* |
| CD163 density in tumor (%) | 0.8 +/- 0.6 | 2.3 +/- 1.2* |
| CD163 density in TINT (%) | 1.0 +/- 0.22 | 2.8 +/- 0.59* |
| Mast cell density in TINT (%) | 0.30 +/- 0.07 | 0.34 +/- 0.12 |
| Blood vessel density in TINT (%) | 1.9 +/- 0.37 | 1.7 +/- 0.40 |
| Endothelial BrdU labeling in TINT | 23 +/- 4.5 | 32 +/- 11 |
| Mural cell BrdU labeling in TINT | 10 +/- 0.1 | 42 +/- 16* |
| Hypoxyprobe stained TINT (%) | 7.4 +/- 2.0 | 3.9 +/- 1.6* |
Values are mean+/-SD
* significantly different than in AT-1 tumor bearing animals (p<0.05), TINT; Tumor instructed normal tissue (normal prostate tissue in the tumor-bearing organ).