Table 2. Significant co-stimulatory/regulatory effects (Bonferroni p < 0.05 or large effect and FDR< 0.05) and independent data validation status.
Bold text highlights the specific hypothesis. WT1 was not measured in the validation data.
| Median Months PFS | Discovery Adjusted | Validation Adjusted | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CD3 Low | CD3 High | ||||||||
| Gene | % High | Low | High | Low | High | p-value | FDR | p-value | |
| Regulatory | MAGEA8 | 50% | 13.8 | 17.4 | 26.8 | 15.4 | 0.0266 | 0.0133 | 0.0291 |
| FAS | 40% | 14.1 | 17.9 | 23.8 | 16.1 | 0.0112 | 0.0111 | 0.3081 | |
| TLR7 | 70% | 14.8 | 14.9 | 34.0 | 18.0 | 1.0000 | 0.0499 | 0.0286 | |
| Stimulatory | MPL | 70% | 15.1 | 14.8 | 15.4 | 24.2 | 0.0456 | 0.0153 | 0.0155 |
| AMHR2 | WT1 | 70% | 14.6 | 14.8 | 13.0 | 22.3 | 0.0134 | 0.0067 | NA |
| AMHR2 | 50% | 13.8 | 17.4 | 14.7 | 25.1 | 0.0071 | 0.0067 | 0.0038 | |
| EPOR | 20% | 14.0 | 16.4 | 18.0 | 40.1 | 0.5330 | 0.0323 | 0.0206 | |