Fig 1. The KATP channel opener cromakalim has ocular hypotensive activity in perfusion cultures of human anterior segments.
A) Representative graph shows reduction in pressure following addition of cromakalim (2 μM). B) Treatment with 2 μM cromakalim caused significant decrease in pressure when compared to vehicle (DMSO) treated controls (n = 9). C) Outflow facility in all eye pairs treated with cromakalim for 24 hours along with the mean value for the group. Outflow facility was increased in 8 out of the 9 eye pairs. Data represents mean ± standard deviation. *p<0.001.