Fig 3. Cromakalim lowered intraocular pressure (IOP) in wild type C57BL/6 mice but not in Kir6.2(-/-) mice.
IOP was significantly reduced within 24 hours of 5 mM cromakalim treatment. Average IOP reduction was calculated to be 3.19 ± 0.41 mmHg over a treatment period of 5 days in wild type mice (n = 10). IOP was found to return to baseline levels within 48 hours of termination of treatment. In contrast, Kir6.2(-/-) mice (n = 10) showed no change in IOP following cromakalim treatment. IOP in these animals remained at baseline levels even after topical administration of cromakalim. Values correspond to average difference (in mmHg) between treated and control eyes for individual days (ΔIOP). *p<0.01