Fig 6. Genomic localization of differentially methylated regions.

(A), The proportion of DMRs falling within the promoter, proximal promoter, exonic, intronic or distal promoters in ZY, 4C, 16C and IVP blastocyst groups. (B), Enrichment ratio of hypermethylated regions in gene body and promoter sites in ZY, 4C, 16C and IVP blastocyst groups. Positive log₂ enrichment indicates higher proportion of the hypermethylated probes at the proximal promoter, promoter, distal promoter, intron or exon regions. The proximal promoter, promoter and distal promoter regions are defined as the first 1 kbp, 5 kbp and 50 kbp from the transcription start site, respectively and probes which are not within the "Distal promoter" distance were classified as "no nearby gene".