Fig 3. Average log₁₀-reduction in MRSA USA300 burden in infected murine skin wounds.

Evaluating the effectiveness of treatment of MRSA skin lesions in mice with mupirocin (2%), thiazole compounds 1–5 (2%), and compound 1 (2%, using Lipoderm as the vehicle) twice daily for three days. The average log₁₀-reduction in bacterial burden (relative to the negative control group (petroleum jelly)) was calculated and presented in the figure. Error bars represent standard deviation values. A one-way ANOVA, with post hoc Holm-Sidak’s multiple comparisons test revealed statistical difference (denoted by asterisk) between compounds 1, 3, 4, 5, 1 (using Lipoderm as the vehicle), and mupirocin relative to the negative control (P < 0.05).