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. Author manuscript; available in PMC: 2015 Nov 4.
Published in final edited form as: Neuropharmacology. 2013 Sep 18;77:145–155. doi: 10.1016/j.neuropharm.2013.09.003

Table 2.

Summary of apical dendrite phenotype and nAChR current amplitudes in young and adult wildtype and α5−/− mice treated developmentally with in vivo nicotine or vehicle control.

Young mice Adult mice
Wildtype (Vehicle control)

  • Immature pattern of apical dendrite morphology

  • High nAChR currents (108 ± 12 pA)

  • Mature pattern of apical dendrite morphology

  • Medium nAChR currents (80 ± 8 pA)
Wildtype (In vivo nicotine)

  • Exaggerated immature pattern of apical dendrite morphology

  • Low nAChR currents as “in vivo average” (60 ± 6 pA). Extremely low nAChR current after acute nicotine (36 ± 4 pA). Medium nAChR current on nicotine washout (84 ± 9 pA).

  • Immature pattern of apical dendrite morphology

  • Low nAChR currents (66 ± 4 pA)
α5−/− (Vehicle control)

  • Immature pattern of apical dendrite morphology

  • Low nAChR currents (71 ± 8 pA)

  • Immature pattern of apical dendrite morphology

  • Very low nAChR currents (50 ± 4 pA)
α5−/− (In vivo nicotine)

  • Immature pattern of apical dendrite morphology

  • Low nAChR currents as “in vivo average” (61 ± 6 pA). Extremely low nAChR current after acute nicotine (26 ± 3 pA). High nAChR current on nicotine washout (97 ± 10 pA).

  • Mature pattern of apical dendrite morphology

  • Low nAChR currents (65 ± 5 pA)

Bold, italic text is used to indicate specific nAChR current amplitude hypothesized to influence adult apical dendrite morphology. High nAChR currents in young mice may trigger the apical dendrite retraction necessary for the mature pattern of adult apical dendrite morphology.