Table 2.

Recommended Dosing Schedules of PPIs - Pharmacokinetic Properties

PPI	Dosing With Meals	Food Effect
Omeprazole (20mg)	Before eating	Not available
Lansoprazole (30,60mg)	With or without food	12-55% increase in Cmax and 9-37% increase in AUC
Esomeprazole (40mg)	At least 1 hour before eating	33-50% decrease in AUC after food intake compared to fasting conditions
Pantoprazole (40mg)	With or without food	Absorption may be delayed up to 2 hours or longer with food Cmax and AUC not altered
Rabeprazole (20mg)	With or without food	Absorption may be delayed up to 4 hours or longer when administered with a high fat meal. Tmax is variable, Cmax and AUC not altered

Cmax = Maximum plasma concentration; Tmax = Time to reach maximum concentration