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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Cancer Prev Res (Phila). 2015 Aug 31;8(11):1076–1083. doi: 10.1158/1940-6207.CAPR-15-0147

Fig. 1.

Fig. 1

Colocalization photomicrograph (400×) of proliferation, p27Kip1, differentiation and apoptosis in serial sections. A: Proliferation (Ki-67, orange) was predominantly localized to the lower part of the crypts and p27Kip1 (green) staining was localized in the nuclei of colonic cells within crypts. B: lectin binding (red) was primarily located in the upper part of the crypt and apoptotic cells (green) were found in the lower region of the crypt 9 h after AOM injection. Blue staining represents DAPI counterstaining. Panels A and B are derived from serial sections and crypts 1–5 in panel A are the same crypts shown in panel B. Arrows show the same cell labeled for cell proliferation and p27 Kip1 in panel A, and apoptosis in panel B.