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. Author manuscript; available in PMC: 2016 Dec 3.
Published in final edited form as: Neuroscience. 2015 Sep 25;310:252–267. doi: 10.1016/j.neuroscience.2015.09.035

Figure 4. Lack of interaction between melanocortin 4 and 5 receptor (MC4R, MC5R) pharmacologic agents.

Figure 4

Increases in physical activity induced by melanocortin receptor agonists were not suppressed by pre-treatment with antagonists to the alternate receptor in perifornical lateral hypothalamus (PeFLH) of high-capacity runner (HCR) rats. Veh: vehicle; 4Ag: MC4R agonist; 4Antag: MC4R antagonist; 5Ag: MC5R agonist; 5Antag: MC5R antagonist. N=7, data represent mean plus SEM *Different from vehicle (p<0.05), NS not significant.