Skip to main content
. Author manuscript; available in PMC: 2016 Dec 3.
Published in final edited form as: Neuroscience. 2015 Sep 25;310:252–267. doi: 10.1016/j.neuroscience.2015.09.035

Figure 5. Food intake and body weight was not impacted by melanocortin receptor agents.

Figure 5

Cumulative food intake with MC4R agonist and antagonist treatments in (A) perifornical lateral hypothalamus (PeFLH) and (E) paraventricular nucleus (PVN); MC5R and antagonist treatments in (C) PeFLH and (G) paraventricular nucleus (PVN) of high-capacity runner (HCR) and low-capacity runner (LCR) rats. Change in body weight with MC4R agonist and antagonist in PeFLH (B) and PVN (F), and MC5R agonist and antagonist in PeFLH (D) and PVN (H). No significant differences in body weight and cumulative food intake over 48 hours after microinjecting with MC4R/MC5R agonists (after an overnight fast) or antagonists compared to vehicle treatment between HCR vs. LCR rats. Dose: 20 pmol/200nl. N=7–10 per group, SEMs range from 0.05 to 0.2 for change in body weight, and from 0.2 to 2.6 for food intake.